Publications by authors named "T Ichijo"
Article Synopsis
- * It involved 312 PAC samples and 315 renin samples, finding that PAC values from CLEIA and liquid chromatography/mass spectrometry/mass spectrometry (LC-MS/MS) were highly correlated, while RIA showed more false positives.
- * The results indicate that using PAC from CLEIA improves PA detection rates and that weak mineralocorticoids affect PAC measurements, notably in the traditional RIA method.
Objective Cortisol-producing adenoma (CPA) is a major subtype of functional adrenal tumors. CPAs are generally treated with adrenalectomy; however, it is difficult to predict the ideal duration of glucocorticoid replacement after resection. This study explored pre-operative factors predictive of glucocorticoid replacement therapy duration after CPA resection.
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- The new Japanese guidelines for primary aldosteronism introduce a "borderline range" for functional confirmatory tests, which is not commonly found in other international guidelines.
- This study compared patients in the borderline group to definitive-positive and negative groups using data from a nationwide Japanese registry, analyzing results from 1,785 individuals based on their captopril-challenge test results.
- The findings showed that the borderline group did not differ significantly from the negative group concerning target organ damage, though both groups had higher odds of chronic kidney disease and electrocardiographic abnormalities when compared to definitive-positive patients.
Background: Clinical practice guidelines recommend the Lateralization Index (LI) as the standard for determining surgical eligibility in primary aldosteronism (PA). Our goal was to identify the optimal LI cut-offs in adrenal venous sampling (AVS) for diagnosing PA that is amenable to surgical cure.
Methods: We conducted a retrospective international cohort study across 16 institutions in 11 countries, including 1,550 patients with PA who underwent AVS, with and/or without ACTH stimulation.