Publications by authors named "T ISHIZAKI"
Many Plasmodium genes remain uncharacterized due to low genetic tractability. Previous large-scale knockout screens have only been able to target about half of the genome in the more genetically tractable rodent malaria parasite Plasmodium berghei. To overcome this limitation, we have developed a scalable CRISPR system called P.
View Article and Find Full Text PDFPurpose: Although the association between oral health and physical frailty is well established, psychological frailty has not been investigated. Therefore, this prospective cohort study was conducted to examine the association between masticatory performance and psychological frailty in older community-dwelling Japanese individuals.
Methods: The participants included 498 older adults who completed baseline and 3- and 6-year follow-up surveys.
Article Synopsis
- The study investigated the link between oral function and mental health among older adults in Japan, focusing on the roles of fruit and vegetable consumption and social interactions.
- Involving 478 participants aged 75 and older, the research used structural equation modeling to show that better oral function positively impacts mental health status, while fruit and vegetable intake and social interactions serve as mediators in this relationship.
- Results indicated a direct association between oral function and mental health, but the mediation analysis showed that the relationship was primarily indirect, driven by dietary habits and social engagement.
Background: Abrupt discontinuation of overused medications is standard treatment for medication overuse headache (MOH), but discontinuation is difficult to maintain. The aim was to evaluate the real-world clinical results of anti-calcitonin gene-related peptide monoclonal antibody (CGRP-mAb) treatment for migraine with MOH without abrupt drug discontinuation and no hospitalization.
Methods: Data were collected before starting CGRP-mAb injections (baseline) and 1 month after each injection.