IMPACT OF PERCUTANEOUS CORONARY INTERVENTION ON PROTHROMBOGENIC POTENTIAL IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2.

Objective: The aim: Aim of study is to assess the influence of urgent reperfusion strategy on the levels of vWf, PAI-1 and sCD40L in patients with acute myocardial infarction (AMI) and concomitant diabetes mellitus type 2 (DM2).

Patients And Methods: Materials and methods: 255 patients with acute myocardial infarction took part in the study, they were divided into four groups depending on the presence of concomitant diabetes mellitus type 2 and performed treatment: I group - 83 diabetic patients who were underwent urgent reperfusion therapy; II group - 60 diabetic patients who received standard anticoagulant therapy; III group - 65 non-diabetic patients who were underwent urgent reperfusion therapy; IV group - 47 non-diabetic patients who received standard anticoagulant therapy. The levels of von Willebrand factor, PAI-1 and sCD40L were determined by enzyme-linked immunosorbent assay.

IMPACT OF PERCUTANEOUS CORONARY INTERVENTION ON MARKERS OF MATRIX DEGRADATION AND ENDOTHELIAL-DEPENDENT MEDIATORS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2.

Aim of study ‒ assess an impact of percutaneous coronary intervention on markers of matrix degradation (MMP-13, TIMP-4) and endothelial-dependent mediators (sVE-cadherin, ADMA) in patients with acute myocardial infarction and diabetes mellitus type 2. 110 patients with AMI were enrolled in the study, 70 patients had concomitant diabetes mellitus type 2. They were additionally divided into two subgroups depending on the treatment (percutaneous coronary intervention or conservative therapy).

[Dynamics of viral hepatitis A morbidity in Minsk].

The results of the analysis of hepatitis A morbidity during the period of 1996 - 2001, are presented. The cyclic character of this morbidity in its dynamics over the period of several years was noted with the maximum morbidity level reached in 2000. The monthly dynamics of hepatitis A morbidity reflected its seasonal character with the maximum increase in autumn and winter.

[Radionuclide biokinetics as a function of the age of experimental animals].

Behaviour of radionuclides with different distribution types in the organism of animals of various ages was studied. Depending on the age of experimental animals, an essential difference in biokinetic parameters such as coefficients of absorbtion from gastro-intestinal tract, distribution and retention levels in critical organs, retention and excretion rates of radionuclides was found.

[The significance of modifying factors in evaluating the effect of radionuclides].

The authors provide the data obtained in experimental animals, pertaining to the influence of certain modifying factors on metabolism and biological effects induced by radioactive isotopes of iodine, by transuranium elements and beryllium. Out of all the modifying factors investigated, the form of the introduced compound and age turned out the most significant ones.