[Clinical significance of cyclic nucleotide metabolism and calcium level in children with arrhythmia].

The cyclic nucleotides (CN) system and Ca2+ content were examined in children with various heart rhythm disorders (HRD). Marked changes were demonstrated which correlated to clinical manifestations of the arrhythmias: their type, phase, duration and favorable changes in their course. Antiarrhythmic therapy was associated with a normalization of the altered levels of cyclase components and Ca2+.

[Characteristics of phenotype in children with arrhythmia].

Examination of 200 children suffering from arrhythmias made it possible to define specific features of the phenotype, attesting to the pathogenetic relation to the condition of the body connective tissue. The authors describe combinations of the signs for the selection of persons at risk for arrhythmias and mitral valve prolapse.

[Interrelation of changes in the levels of calcium, calmodulin and cyclic nucleotides in children with ectopic types of arrhythmia].

In 61 children with different patterns of ectopic arrhythmias (premature heart beat, paroxysmal and non-paroxysmal tachycardia), the peripheral blood leukocytes and myocardial tissues were examined for the content of calmodulin (CM), ionized calcium (Ca2+) and cyclic nucleotides (CN). The data obtained indicate that the CM-Ca2+ and CN system are involved in the genesis of arrhythmias in children and may be used as additional criteria in the diagnosis of cardiac rhythm abnormalities.

[Effect of phentolamine on the clinical manifestations of the disease and hemodynamics in children with 2d- and 3d-degree atrioventricular block].

Phentolamine has been shown to improve peripheral hemodynamics and have a favorable central hemodynamic effect, reflected in clinical improvement, in children with bradycardia (11 patients with second- or third-degree atrioventricular block) and signs of circulatory insufficiency.