Publications by authors named "T I Sutherland"
Background & Aims: Crohn's perianal fistula healing rates remain low. We evaluated the efficacy of a protocolised multidisciplinary treatment strategy optimising care in adults with Crohn's perianal fistulas.
Methods: A new treatment strategy was established at a single tertiary centre.
Article Synopsis
- Accumulation of hyaluronan (HA) in the lungs is a common response to lung injury, particularly during Nb infection, which leads to tissue damage and prompts a type 2 immune response.
- HA levels peaked seven days post-infection, correlating with lung damage and immune involvement, specifically characterized by eosinophils and increased IL-13 cytokines.
- The study shows that HA accumulation is dependent on IL-13, highlighting its role in regulating the HA matrix and supporting lung tissue repair during inflammatory responses.
Purpose: Our aim was to determine whether the administration of a micro-enema immediately prior to prostate MRI is associated with a reduction in rectal gas, gas related artifacts and an improvement in image quality and PI-QUAL score.
Method: This retrospective analysis enrolled 171 patients who underwent multiparametric 3T prostate MRI at our institution between January 2021 and September 2022. 86 patients received a micro-enema, and a further 85 patients did not.
Article Synopsis
- Crohn's disease strictures are typically managed with a single endoscopic balloon dilation (EBD), but researchers explored the effectiveness of repeat EBD combined with needle-knife stricturotomy (NKSt) alongside aggressive drug therapy.
- In a study of 21 patients, those receiving intensive treatment (multiple EBDs and/or NKSt) showed a higher symptom improvement rate (72%) compared to those with a single EBD (40%).
- The findings suggest that repeat dilations and NKSt are safe and potentially more effective for treating strictures, especially when paired with enhanced drug treatment for inflammation.