Publications by authors named "T I Shabatina"
The use of medicinal substances in nanosized forms (nanoforms, nanoparticles) allows the therapeutic effectiveness of pharmaceutical preparations to be increased due to several factors: (1) the high specific surface area of nanomaterials, and (2) the high concentration of surface-active centers interacting with biological objects. In the case of drug nanoforms, even low concentrations of a bioactive substance can have a significant therapeutic effect on living organisms. These effects allow pharmacists to use lower doses of active components, consequently lowering the toxic side effects of pharmaceutical nanoform preparations.
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- Recent advancements in antiviral and anticancer treatments involve inorganic nanoparticles (INPs) like metal and metal oxides, which can be easily modified for improved stability and reduced toxicity.
- Magnetic nanoparticles (MNPs) are particularly promising for enhancing MRI contrast and enabling targeted cancer therapy through hyperthermia using an external magnetic field.
- The review highlights the multifunctional applications of INPs in drug delivery, magnetic therapy, and plasmonic therapies, showcasing their potential in both antitumor and antiviral therapies.
The appearance and increasing number of microorganisms resistant to the action of antibiotics is one of the global problems of the 21st century. Already, the duration of therapeutic treatment and mortality from infectious diseases caused by pathogenic microorganisms have increased significantly over the last few decades. Nanoscale inorganic materials (metals and metal oxides) with antimicrobial potential are a promising solution to this problem.
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- Targeted drug release involves using biocompatible polymer carriers to deliver medications effectively.
- Researchers developed cryogenically structured carriers from alginate and chondroitin sulfate and assessed their properties and drug release capabilities.
- The study found that the concentration and ratio of these polymers significantly influenced swelling and porosity, with chondroitin sulfate affecting the release rate of certain antibiotics like gentamicin while having minimal impact on others like dioxidine.
The increasing appearance of new strains of microorganisms resistant to the action of existing antibiotics is a modern problem that requires urgent decision. A promising potential solution is the use of nanoparticles of bioactive metals and their oxides as new antibacterial agents, since they are capable of affecting pathogenic microorganisms by mechanisms different from the mechanisms of action of antibiotics. Inorganic nanoparticles possess a wide spectrum of antibacterial activity.
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