Publications by authors named "T I Samoylova"

This paper deals with the effect of photobiomodulation (PBM) on Daphnia magna S. and their sensitivity to cadmium sulfate, a known high toxic pollutant. In a first series of experiments, the effect of different He-Ne laser fluences irradiation (range 0.

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Article Synopsis
  • Researchers developed a phage-GnRH vaccine aimed at reducing reproductive capabilities in cats, building on previous findings in mice that showed antibody production against GnRH and suppressed testosterone levels.
  • The study involved injecting male cats with different treatment regimens of the vaccine and monitoring anti-GnRH antibodies, testosterone levels, testicular volume, and sperm characteristics over several months.
  • Results indicated significant antibody response and testosterone suppression, alongside reduced testicular volume and altered sperm morphology, suggesting the vaccine's potential for fertility control, but further optimization and age-related efficacy studies are needed.
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Overpopulation of free-roaming and wildlife animals negatively affects economy and public health in many parts of the world. Contraceptive vaccines are viewed as a valuable option for reducing numbers of unwanted animals. This study develops vaccines for potential use in animal contraception exploiting a DNA platform.

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Background: Population control of domestic, wild, invasive, and captive animal species is a global issue of importance to public health, animal welfare and the economy. There is pressing need for effective, safe, and inexpensive contraceptive technologies to address this problem. Contraceptive vaccines, designed to stimulate the immune system in order to block critical reproductive events and suppress fertility, may provide a solution.

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Phage display is based on genetic engineering of phage coat proteins resulting in fusion peptides displayed on the surface of phage particles. The technology is widely used for generation of phages with novel characteristics for numerous applications in biomedicine and far beyond. The focus of this study was on development of phage-peptide constructs that stimulate production of antibodies against gonadotropin releasing hormone (GnRH).

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