Increased single-strand annealing rather than non-homologous end-joining predicts hereditary ovarian carcinoma.

Mutations in genes encoding DNA double-strand break (DSB) repair components, especially homologous recombination (HR) proteins, were found to predispose to breast and ovarian cancer. Beyond high penetrance risk gene mutations underlying monogenic defects, low risk gene mutations generate polygenic defects, enlarging the fraction of individuals with a predisposing phenotype. DSB repair dysfunction opens new options for targeted therapies; poly (ADP-ribose) polymerase (PARP) inhibitors have been approved for BRCA-mutated and platinum-responsive ovarian cancers.

[A method for predicting the development of circulatory encephalopathy in patients with autonomic vascular dystonia].

Overall 300 patients aged between 35 to 40 years, suffering from constitutional vasoneurosis (CVN) were examined. The analysis of the time-related course of psychopathological manifestations in the above patients was found out to be of prognostic value: in a debut of CVN with vasovegetative disorders there develops discirculatory encephalopathy, that of CVN presenting with neurotic syndromes leads to different manifestations of anxious syndrome, panic attacks included.