Prognostic Factors for Nonasphyxia-Related Cardiac Arrest Patients Undergoing Extracorporeal Rewarming - HELP Registry Study.

Objective: Extracorporeal rewarming is the treatment of choice for patients who had hypothermic cardiac arrest, allowing for best neurologic outcome. The authors' goal was to identify factors associated with survival in nonasphyxia-related hypothermic cardiac arrest patients undergoing extracorporeal rewarming.

Design: All 38 cardiac surgery departments in Poland were encouraged to report consecutive hypothermic cardiac arrest patients treated with extracorporeal life support.

[Pathophysiological mechanisms of portal hypertension syndrome development].

This review presents modern understanding of the pathophysiological mechanisms which lead to intrahepatic portal hypertension syndrome, as well as the development of main complications, such as esophageal varices, cardial bleeding, ascites, hypersplenism.

[Specific features of abdominal perfusion remodeling at different stages of portal hypertensive syndrome].

The specific features of abdominal blood flow remodulation, especially of arterial, portal and caval systems were studied, including their interactions and mutual influence at different stages of portal hypertension syndrome. According to the received conclusions treatment reccomendations are given.

[Synergistic effect of rib80 and hit mutations on riboflavin biosynthesis and iron transport in the yeast Pichia guilliermondii].

Mutant strains of the yeast Pichia guilliermondii, carrying both rib80 and hit mutations in a haploid genome, were derived from previously obtained strains with defective rib80 or hit genes, exerting negative control of the riboflavin biosynthesis and iron transport in Pichia guilliermondii. The double mutant rib80hit strains exhibited an increased level of riboflavin biosynthesis and higher activities of GTP cyclohydrolase and riboflavin synthetase. Iron deficiency caused an additional increase in riboflavin overproduction.