Modularity of PRC1 composition and chromatin interaction define condensate properties.

Polycomb repressive complexes (PRCs) play a key role in gene repression and are indispensable for proper development. Canonical PRC1 forms condensates in vitro and in cells that are proposed to contribute to the maintenance of repression. However, how chromatin and the various subunits of PRC1 contribute to condensation is largely unexplored.

Child abuse and neglect during the COVID-19 pandemic: An umbrella review.

Background: During the COVID-19 pandemic, multiple child health experts postulated that the stay-at-home orders would negatively impact child abuse and neglect.

Objectives: We aimed to examine the impact of the COVID-19 pandemic on child abuse and neglect in children ages 18 and under; and review author recommendations for future emergency lockdown procedures.

Methods: We completed a systematic search of articles across five databases.

Modularity of PRC1 Composition and Chromatin Interaction define Condensate Properties.

Polycomb repressive complexes (PRC) play a key role in gene repression and are indispensable for proper development. Canonical PRC1 forms condensates and in cells and the ability of PRC1 to form condensates has been proposed to contribute to maintenance of repression. However, how chromatin and the various subunits of PRC1 contribute to condensation is largely unexplored.

The cognitive control mechanism of improving emotion regulation: A high-definition tDCS and ERP study.

Background: Cognitive reappraisal as a commonly used emotion regulation strategy includes reinterpretation and detachment and is associated with the activity of the dorsolateral prefrontal cortex (DLPFC). However, the neuroenhancement mechanisms of transcranial direct current stimulation (tDCS) over DLPFC that modulate cognitive reappraisal are not yet fully understood. This work aims to verify the causal role of DLPFC in different tactics of cognitive reappraisal and further explore the cognitive control mechanisms of emotion regulation.

Meditation Quality Matters: Effects of Loving-Kindness and Compassion Meditations on Subjective Well-being are Associated with Meditation Quality.

Unlabelled: Loving-kindness and compassion meditations (LKCM) are considered a promising practice for increasing long-term well-being. While previous studies have mainly focused on meditation practice quantity, the current study provides an initial exploration of the quality of meditation during multiweek LKCM training. Data were collected through offline (Study 1;  = 41) and online (Study 2;  = 243) LKCM interventions.