[The development of a radioimmunological method for determining autoantibodies to thyroglobulin].

A radioimmunoassay to determine a titer of autoantibodies to thyroglobulin in human blood serum was developed. The scheme of analysis included a reaction between 125I-thyroglobulin and autoantibodies to thyroglobulin with subsequent separation of the produced immune complex and free polyethylene glycol-labeled thyroglobulin. A high specificity of the radioimmunoassay is ensured by the use of highly purified thyroglobulin for obtaining the labeled agent.

[Serum thyroglobulin in thyroid cancer and other thyroid diseases].

The authors have used radioimmunoassay to measure blood serum thyroglobulin (TG) in 257 patients with benign processes and 118 ones with carcinoma of the thyroid and came to a conclusion that this method is unfit for the differential diagnosis between these conditions. Serum TG level is in good correlation with the results of treatment of thyroid carcinoma patients: in radically treated ones blood serum TG level reduces to the norm, and when recurrences or metastases develop it significantly increases. Therefore, radioimmunoassay is recommended for early detection of thyroid carcinoma recurrences and metastases in follow-up of patients with this condition.