[The requirements of standard and conditions of interchangeability of medical articles].

The article deals with possibility to apply specific approaches under evaluation of interchangeability of medical articles for laboratory analysis. The development of standardized analytical technologies of laboratory medicine and formulation of requirements of standards addressed to manufacturers of medical articles the clinically validated requirements are to be followed. These requirements include sensitivity and specificity of techniques, accuracy and precision of research results, stability of reagents' quality in particular conditions of their transportation and storage.

[The public health state study as part of the risk assessment methodology].

Comparative analysis of information value of the official data sources on disease incidence and public state of health with regards to the risk assessment methodology has been made in the article. Each out of the three information sources studied here must be taken into consideration when performing risk assessment projects, for the data obtained give necessary supplementary knowledge on the human health which, in its turn, allows to determine the enterprises (production units) substantially contributing to environmental contamination in the area, and thus to develop and take appropriate management decisions towards them.

[The preanalytical stage of under measuring of concentration of catalytic activity of enzymes: the characteristics and tasks of standardization].

The article explains the importance of standardization, the development and maintenance of rules and recommendations regulating the conditions and order of implementation of particular parts of preanalytical stage. The order of these conditions is noted including the rules stated and published in such normative documents as national standards GOST R 15 189-2009, GOST R 53079.4-2008, GOST R ISO 6710-209 and in the recommendations of foreign National societies ofclini-cal chemistry and laboratory medicine.

[Influence of hospital factors on the spread of nosocomial infections].

The incidence of nosocomial infections (NI) was analyzed and the specific features of their occurrence and spread were defined at a multidisciplinary emergency care hospital. Weight coefficients were calculated for the hospital factors influencing NI, which allowed corrections to be made into the priority measures of the existing NI prevention system.