Publications by authors named "T I Losik"

Experimental studies covered thermoregulatory reactions of feet and hands, when using equipment protecting distal parts of hands and feet and using "active" heating (electric heating and thermochemical heater). Findings are that "active" heaters with output range 4-8 watt, as electrically heated inserts in gauntlets and welts, at air temperatures of -5 to -10 degrees C maintained average skin temperature of hand at 17-20 degrees C; using "active" heaters with output of 12 watt increased heat insulation of gauntlets and shoes up to 0.609-0.

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Studies of heat state of human involved into physical work in heating environment and having various protective clothing on demonstrated value of the protective clothing in modifying thermal load on the body and possible decrease of this load through air temperature and humidity correction, shorter stay at workplace. The authors presented hygienic requirements to air temperatures range in accordance with allowable body heating degree, suggested mathematic model to forecast integral parameter of human functional state in accordance with type of protective clothing applied. The article also covers necessity of upper air temperature limit during hot season, for applying protective clothing made of materials with low air permeability and hydraulic conductivity.

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The article covers results of studies conducted over last 15 years and aimed to elaboration of requirements to integral parameters of microclimate at workplace, its evaluation and regulation, prophylactic measures against body overcooling and overheating. The authors present methods to evaluate combined effects of physical factors (noise, vibration, microclimate) and to assess microclimate with consideration of factors determining body thermal load (energy expenditure, duration of stay at workplace, heat insulation of clothes and thermo-physical parameters of its materials). Mathematic models of forecasting cold and heat stress are presented, as well as requirements to heat insulation for individual protective means against cold and methods to calculate it.

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Honokiol, a compound extracted from Magnolia officinalis, has antitumor and antiangiogenic properties in several tumor models in vivo. Among the downstream pathways inhibited by honokiol is nuclear factor kappa beta (NFkappabeta). A prime physiologic stimulus of NFkappabeta is reactive oxygen species.

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Based on mathematic and statistic analysis of results obtained in studies of human heat exchange with cooling water medium, the authors represented canonical correlational patterns to determine integral parameter of cooling conditions (IPCC) referred to naked human and with various clothes on, both with and without additional heat releasing sources. Mathematic and statistic analysis helped to present correlational patterns for predicting levels of changes in human functional state according to IPCC comprising complex of factors that determine heat exchange in water medium, including safe time for stay in it.

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