[Etiology of influenza according to the data of serological diagnostics in hospital patients in St. Petersburg at the period of 1968 - 2000].

The specific features of the etiology of influenza in children and adults at the period of the simultaneous circulation of two subtypes of influenza virus A, according to the results in the hemagglutination-inhibition reaction in 261,490 influenza and ARD patients hospitalized in St. Petersburg in the course of 32 years, were analyzed. The results of serological diagnostics was shown to correspond to the data of the identification of influenza viruses in Russia and all over the world.

[Assesment of the specific oxidase activity of ceruloplasmin in pregnant women].

The specific oxidase activity of ceruloplasmin (activity per unit mass of enzyme protein) was studied in plasma of pregnant women with gestosis, feto-placental insufficiency, postmature and in normal pregnancy. The specific oxidase activity decreased in all groups with pathology. The ceruloplasmin concentration decreased in the postmature group.

[Dynamics of oxidase activity in blood plasma upon intravenous and intramuscular administration of ceruloplasmin].

Oxidase activity dynamics in the blood plasma of test animals was studied upon intravenous and intramuscular injections of ceruloplasmin. It was found that the enzymatic activity does not reflect the content of drug in the blood plasma and is not always correlated with the amount of exogenously introduced drug. Intramuscular injections can also be used for the administration of ceruloplasmin.

[Antioxidant and antihypoxic effects of the ceruloplasmin preparation in the hypobaric hypoxia model].

The antioxidant and antihypoxant effects of the drug ceruloplasmin were studied on an experimental model of hypobaric hypoxia in rats. Two forms of the drug characterized by low and high enzymatic activity were administered (intramuscularly or intraperitoneally) 20 min or 1 day before hypobaric hypoxia test. The drug effect was independent of the enzymatic activity level.

[The immunoprophylaxis of influenza among elderly persons].

During three seasons at the period of 1992-1996 immunization of elderly persons, living in homes for old people, against influenza with inactivated influenza vaccine (IIV) was carried out. Altogether 856 persons were immunized intranasally, 581 persons constituting the control group. For comparison, 4,825 healthy young adults aged 18-24 years were immunized under similar conditions.