Production and radiochemistry of antimony-120m: Efforts toward Auger electron therapy with Sb.

Targeted Meitner-Auger Therapy (TMAT) has potential for personalized treatment thanks to its subcellular dosimetric selectivity, which is distinct from the dosimetry of β and α particle emission based Targeted Radionuclide Therapy (TRT). To date, most clinical and preclinical TMAT studies have used commercially available radionuclides. These studies showed promising results despite using radionuclides with theoretically suboptimal photon to electron ratios, decay kinetics, and electron emission spectra.

Getting a lead on Pb-amide chelators for Pb radiopharmaceuticals.

Amide-based chelators DTPAm, EGTAm and ampam were synthesized to investigate which chelator most ideally coordinates [Pb]Pb ions for potential radiopharmaceutical applications. H NMR spectroscopy was used to study each metal-ligand complex in the solution state. The H NMR spectrum of [Pb(DTPAm)] revealed minimal isomerization and fluxional behaviour compared to [Pb(EGTAm)] and [Pb(ampam)], both of which showed fewer spectral changes indicative of less static behaviour.

Phosphonate Chelators for Medicinal Metal Ions.

A family of phosphonate-bearing chelators was synthesized to study their potential in metal-based (radio)pharmaceuticals. Three ligands (Hphospa, Hdipedpa, Heppy; structures illustrated in manuscript) were fully characterized, including X-ray crystallographic structures of Hphospa and Hdipedpa. NMR spectroscopy techniques were used to confirm the complexation of each ligand with selected trivalent metal ions.

Evaluation of La(XT), a novel lanthanide compound, in an OVX rat model of osteoporosis.

Purpose: The purpose of this study was to evaluate the efficacy and toxicity of a novel lanthanum compound, La(XT), in an ovariectomized (OVX) rat model of osteoporosis.

Methods: Twenty-four ovariectomized female Sprague Dawley rats were divided into 3 groups receiving a research diet with/without treatment compounds (alendronate: 3 mg/kg; La(XT) 100 mg/kg) for three months. At the time of sacrifice, the kidney, liver, brain, lung and spleen were collected for histological examination.

Rapid Thermodynamically Stable Complex Formation of [In]In, [Y]Y, and [Lu]Lu with Hdappa.

A phosphinate-bearing picolinic acid-based chelating ligand (Hdappa) was synthesized and characterized to assess its potential as a bifunctional chelator (BFC) for inorganic radiopharmaceuticals. Nuclear magnetic resonance (NMR) spectroscopy was employed to investigate the chelator coordination chemistry with a variety of nonradioactive trivalent metal ions (In, Lu, Y, Sc, La, Bi). Density functional theory (DFT) calculations explored the coordination environments of aforementioned metal complexes.