Effect of Phlorotannins from Brown Algae on α--Acetylgalactosaminidase Produced by Duodenal Adenocarcinoma and Melanoma Cells.

The inhibitor of human α-N-acetylgalactosaminidase (α-NaGalase) was isolated from a water-ethanol extract of the brown algae . Currently, tumor α-NaGalase is considered to be a therapeutic target in the treatment of cancer. According to NMR spectroscopy and mass spectrometric analysis, it is a high-molecular-weight fraction of phlorethols with a degree of polymerization (DP) equaling 11-23 phloroglucinols (CcPh).

Structural diversity of fucoidans and their radioprotective effect.

Fucoidans are biologically active sulfated polysaccharides of brown algae. They have a great structural diversity and a wide spectrum of biological activity. This review is intended to outline what is currently known about the structures of fucoidans and their radioprotective effect.

In Vitro Anticancer and Radiosensitizing Activities of Phlorethols from the Brown Alga .

The anticancer and radiosensitizing effects of high-molecular-weight phlorethols (Mw = 2520 Da) isolated from the brown algae of on human colorectal carcinoma HCT 116 and HT-29 cells were investigated. Phlorethols possessed cytotoxic activity against HT-29 (IC = 92 μg/mL) and HCT 116 (IC = 94 μg/mL) cells. at non-toxic concentrations inhibited the colony formation in colon cancer cells and significantly enhanced their sensitivity to low non-toxic X-ray irradiation.

Is the transformation of fucoidans in human body possible?

Fucoidans are a group of homo-and hetero-polysaccharides, which necessarily contains residues of sulfated α-L-fucose. Fucoidans are found only in brown algae. These polysaccharides exhibit a wide spectrum of biological activity and have a great therapeutic potential.

[Antiviral action and pathogenetic targets for seaweed sulfated polysaccharides in herpesvirus infections].

The review summarizes results of studies of effects of sulfated polysaccharides from seaweed on herpesviruses and the course of herpesvirus infections. Importance of this problem is determined by the prevalence of herpesviruses that can persist in the human body and demonstrate a high degree of immune mimicry and resistance to antiviral agents. A wide range of physiological action of sulfated polysaccharides, receptor agonists of innate and adaptive immune cells, which possess potent antiviral, antioxidant and anti-inflammatory activities, open the possibility of their use for creation of new generation pharmacological substances and agents with associated activity for the treatment of herpesvirus infections.