[Prevalence and risk factors of delirium in COVID-19].

Objective: To assess the frequency and risk factors of delirium in patients hospitalized with COVID-19.

Material And Methods: Four hundred and forty patients admitted to the Infectious Diseases Hospital of the University Clinical Hospital No.3 of Sechenov University were included in the study.

[Psychopharmacotherapy of late-stage hypochondriac conditions: frequency of use and effectiveness of drugs].

Objective: To conduct a comparative analysis of psychopharmacotherapy effectiveness in hypochondriac disorders of late age and to identify the optimal combinations of drugs depending on the thymopathic (hypothymic and/or anxiety) components accompanying the main hypochondriac manifestation.

Material And Methods: One hundred and eight female inpatients, aged from 50 to 88 years, with leading hypochondriac symptoms of non-delusional level were enrolled in the study. All patients were examined clinically and psychopathologically using psychometric scales: the Montgomery-Asberg Depression Rating Scale, the Hamilton Anxiety Rating Scale, the hypochondria rating scale and the UKU side-effect rating scale.

[The current state and future prospects of depression research (clinical and classification problems)].

Despite decades of research, neurobiological studies of depression haven't achieved significant results. Many experts propose that one of the main reasons for this failure is current diagnostic standards not considering the heterogeneity and polymorphism of depression. Research is unable to identify specific neurobiological changes due to formal diagnosis 'major depressive disorder' and new diagnostic criteria are needed.

[Genetic and clinical predictors of treatment efficacy in depressive disorders].

Aim: To study clinical and genetic characteristics that impact on the efficacy of pharmacotherapy of depressive disorders.

Material And Methods: The study included 188 patients with unipolar depressive disorders of different genesis (psychogenic, endogenous and organic). A clinical-psychopathological method and depression psychometric scales were used.

[The possibility of using standardized self-report anxiety and depression scales in elderly patients: Depression scales/questionnaires in elderly].

Aim: To study possibilities of using depression scales in elderly patients, evaluate the parameters of their reliability and validity and develop practical recommendations on the use of these scales in clinical practice.

Material And Methods: The study included 234 patients, aged over 50 years, with anxious depression. The following scales/questionnaires BDI, GDS-15, CES-D-10, CES-D-20, ZDS and HADS-D were used at baseline and 12 weeks after treatment.