Postmortem analyses of myocardial microRNA expression in sepsis.

Background: Sepsis can lead to myocardial depression, playing a significant role in sepsis pathophysiology, clinical care, and outcome. To gain more insight into the pathophysiology of the myocardial response in sepsis, we investigated the expression of microRNA in myocardial autopsy specimens in critically ill deceased with sepsis and non-septic controls.

Materials And Methods: In this retrospective observational study, we obtained myocardial tissue samples collected during autopsy from adult patients deceased with sepsis (n = 15) for routine histological examination.

Health status and quality of life before critical illness: Northern Finland Birth Cohort 1966 study.

Background: Previous findings support the claim intensive care unit (ICU) patients have a higher rate of comorbidities and reduction of health- and functional status compared with the normal population.

Aim: In this prospective observational study, our aim was to determine those health-related factors at the age of 31 years which were associated with a later critical illness among previously un-hospitalized individuals by exploring data obtained from the Northern Finland Birth Cohort 1966 (NFBC1966).

Methods: NFBC1966 is a Finnish birth cohort, which includes 12,058 live births with expected dates of delivery during 1966.

Long-Term Quality of Life After Pediatric Traumatic Brain Injury Treated in the Intensive Care Unit.

Background: To examine the long-term health-related quality of life (HRQL) after pediatric traumatic brain injury (TBI) treated in the intensive care unit (ICU).

Methods: This retrospective cohort study was conducted using data from four university hospital ICUs in Finland. Children aged < 18 years with TBI treated in the ICU during 2003 to 2013 were included.

Unresponsive Low Mixed Venous Oxygen Saturation During Early Intensive Care Unit Stay is Associated With Increased Risk of Organ Dysfunction After Cardiac Surgery: A Single-Center Retrospective Study.

Objectives: The aim of the study was to determine if unresponsive mixed venous oxygen saturation (SvO) values during early postoperative hours are associated with postoperative organ dysfunction.

Design: A single-center retrospective observational study.

Setting: A university hospital.

Effect of antiplatelet and anticoagulant medication use on injury severity and mortality in patients with traumatic brain injury treated in the intensive care unit.

Background: Antiplatelet and anticoagulant medication are increasingly common and can increase the risks of morbidity and mortality in traumatic brain injury (TBI) patients. Our study aimed to quantify the association of antiplatelet or anticoagulant use in intensive care unit (ICU)-treated TBI patients with 1-year mortality and head CT findings.

Method: We conducted a retrospective, multicenter observational study using the Finnish Intensive Care Consortium database.