Publications by authors named "T I Akaf'eva"
Comparative envaluation of metals content of serum and subcutaneous interstitial fluid revealed that levels of chromium, manganese, arsenic, cadmium in these biologic media have no reliable differences (p = 0.056-0.907) but strong correlation (r = 0.
View Article and Find Full Text PDFNanostructured amorphous silica (SiO2) is one of the priorities of nanomaterials, exposing human to the ever-increasing scale as a component of food additives, drugs and cosmetic products. According to numerous publications SiO2 nanoparticles (NPs) possess deleterious effects on animal and human cells in vitro and also exhibit inhalation toxicity. However, the biological effects in vivo of silica NPs taken orally are studied insufficiently.
View Article and Find Full Text PDFArticle Synopsis
- The study found that nanodispersed manganese oxide (III, IV) is significantly more toxic to white mice when ingested compared to larger particles, showing 2.6 times greater toxicity.
- Health effects observed included vasodilation, increased cell aggregation, and other pathological changes, worsening with higher doses.
- Long-term toxicity predictions indicated lower safe dosage thresholds for nanodispersed manganese oxide, with NOAEL levels being 2.3 times less than those for larger particles.