Publications by authors named "T Hultsch"
The long road to atopic disease modification in infants with atopic dermatitis.
J Eur Acad Dermatol Venereol
April 2024
Article Synopsis
- Cholinergic urticaria (CholU) is a common condition where symptoms like itchy hives arise from sweating, but existing treatments often fail to provide adequate control for patients.
- In a phase IIa trial, the new oral medication izuforant was tested on adults with CholU who didn't respond well to traditional antihistamines.
- Results showed that while izuforant did not significantly improve the primary measures of urticaria activity, it did lead to noticeable improvements in patient-reported severity assessments compared to placebo.
Background: Dupilumab has demonstrated efficacy with acceptable safety in clinical trials in patients with moderate to severe atopic dermatitis (AD).
Objective: To assess dupilumab's impact on asthma and sinonasal conditions in adult patients with moderate to severe AD in four randomized, double-blinded, placebo-controlled trials.
Methods: In LIBERTY AD SOLO 1 (NCT02277743), SOLO 2 (NCT02755649), CHRONOS (NCT02260986), and CAFÉ (NCT02755649), patients received placebo, dupilumab 300 mg every 2 weeks (q2w), or dupilumab 300 mg weekly (qw).
Background: Pain is a frequent symptom of atopic dermatitis (AD).
Objectives: The aims of the study were to evaluate the effects of dupilumab on pain/discomfort in AD and to determine whether pain correlates with other outcomes.
Methods: This was a post hoc analysis of 5 randomized, placebo-controlled clinical trials in which adults with chronic AD received placebo or dupilumab 300 mg every 2 weeks or once weekly with and without topical corticosteroids.
Atopic dermatitis (also known as AD or eczema) is a common skin disease that can cause intense and persistent itching and rashes. Skin creams or ointments are not suitable or effective for some patients with moderate-to-severe AD. In these patients, oral (taken by mouth) or injected medications may be required.
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