Publications by authors named "T Hulgan"
Article Synopsis
- The study investigates the relationship between mitochondrial DNA (mtDNA) variation and neurocognitive impairment in people with HIV (PWH), using MutPred scores to predict variant pathogenicity.
- Researchers analyzed data from 744 PWH in the CHARTER study, finding that those with potentially harmful mtDNA variants were less likely to experience motor impairment.
- The results suggest that these deleterious mtDNA variants may actually protect against motor function decline, indicating complex and not yet understood mechanisms at play.
Pharmacogenetics of weight gain following switch from efavirenz- to integrase inhibitor-containing regimens.
Pharmacogenet Genomics
February 2024
Background: Excessive weight gain affects some persons with HIV after switching to integrase strand transfer inhibitor (INSTI)-containing antiretroviral therapy (ART). We studied associations between CYP2B6 genotype and weight gain after ART switch among ACTG A5001 and A5322 participants.
Methods: Eligible participants switched from efavirenz- to INSTI-containing ART, had genotype data, and had weight data at least once from 4 weeks to 2 years post-switch.
HIV-associated cognitive dysfunction during combination antiretroviral therapy (cART) involves mitochondrial dysfunction, but the impact of contemporary cART on chronic metabolic changes in the brain and in latent HIV infection is unclear. We interrogated mitochondrial function in a human microglia (hμglia) cell line harboring inducible HIV provirus and in SH-SY5Y cells after exposure to individual antiretroviral drugs or cART, using the MitoStress assay. cART-induced changes in protein expression, reactive oxygen species (ROS) production, mitochondrial DNA copy number, and cellular iron were also explored.
View Article and Find Full Text PDFChronic obstructive pulmonary disease (COPD) is one of the most common comorbid diseases among aging people with HIV (PWH) and is often mismanaged. To address this gap, we are conducting the study, "Advancing care for COPD in people living with HIV by Implementing Evidence-based management through proactive E-consults (ACHIEVE)." This intervention optimizes COPD management by promoting effective, evidence-based care and de-implementing inappropriate therapies for COPD in PWH receiving care at Veteran Affairs (VA) medical centers.
View Article and Find Full Text PDFArticle Synopsis
- Veterans think they should get antibiotics when they visit the doctor for respiratory infections, which might affect how happy they are with their visit.
- A study looked at 1,329 Veterans to see if getting antibiotics or expecting them changed their satisfaction scores after their appointment.
- The results showed that those who expected antibiotics were less satisfied, even if they didn't receive any, suggesting that meeting their expectations is important for their satisfaction.