ENALAPRIL EFFECT ON GLUTATHIONE CHAIN OF THE ANTIOXIDANT SYSTEM OF THE BRAIN IN RATS WITH SCOPOLAMINE-INDUCED NEURODEGENERATION.

Objective of the work is to study enalapril effect, a blocker of renin-angiotensin system, on glutathione chain of the antioxidant system of the cerebral cortex and hippocampus of rats with experimental neurodegeneration. The experiments were conducted on nonlinear laboratory albino male rats with their body weight of 0,18-0,20 kg. The model of neurodegeneration was created by means of intraperitoneally administration of scopolamine hydrochloride (Sigma, USA) during 27 days in the dose of 1 mg/kg.

ACETYLATION PHENOTYPE AS A SUSCEPTIBILITY MARKER FOR DEVELOPMENT OF NITRATE-CADMIUM INTOXICATION IN YOUNG RATS.

The article solves a current task concerning a substantiated use of acetylation phenotype as susceptibility biomarker to unfavourable effect of chemical substances in scientific studies. Objective: to study a combined effect of sodium nitrate and cadmium chloride on the prooxidant-antioxidant balance of the blood, liver and functional state of the central nervous system in young rats with different acetylation type. The experimental studies were performed on immature male rats 1,5-month of age.

CHANGES OF PROTEINURIA AND ACID-REGULATING KIDNEY FUNCTION IN MATURE RATS WITH SLOW AND RAPID ACETYLATION TYPE UNDER CONDITIONS OF SUBACUTE CADMIUM-NITRATE INTOXICATION.

The experiments conducted on non-linear mature laboratory albino rats determined that under conditions of subacute cadmium-nitrate intoxication the indices of proteinuria and acid-regulating renal function depend on acetylation phenotype. Unlike rapid acetylators considerable increase of protein concentration in urine (192,8%, р<0,05) and standardized by glomerular filtration protein excretion (141,7%, р<0,05) are indicative of higher susceptibility of rats with slow acetylation type to nephrotoxic action of cadmium chloride and sodium nitrate. Lack of protein loss with urine and adaptive-compensative character of acid-regulating renal function changes directed to elimination of hydrogen ions excess from the body give evidence concerning less intensive damage of the nephron tubular portion in rats with rapid acetylation type, and at the same time do not exclude development of nephropathy.