Metabolic Brain PET Connectivity.

This review examines the role of metabolic connectivity based on fluorodeoxyglucose-PET in understanding brain network organization across neurologic disorders, with a focus on neurodegenerative diseases. The article explores key methodologies for metabolic connectivity study and highlights altered connectivity patterns in Alzheimer's, Parkinson's, frontotemporal dementia, and other conditions. It also discusses emerging applications, including single-subject analyses and brain-organ interactions.

Brain PET Imaging in the Presurgical Evaluation of Drug-Resistant Focal Epilepsy.

Presurgical evaluation aims to localize the seizure onset zone (SOZ) for a tailored resection. Interictal [F]fluorodeoxyglucose PET is now an established test to lateralize and/or localize the SOZ, particularly if MR imaging is negative or if the noninvasive assessment shows discrepancies. PET can show hypometabolic areas associated with SOZ and the potential altered metabolic brain networks.

18F-FDG brain PET: a metabolic predictive factor for gait improvement after cerebrospinal fluid shunting in normal pressure hydrocephalus?

Background: The pathophysiology of normal pressure hydrocephalus (NPH) has not been fully elucidated. Treating NPH with cerebrospinal fluid shunts to improve gait disturbances may have some risks and inconsistent benefits. No clear predictive factor has been identified thus far.

RING1 missense variants reveal sensitivity of DNA damage repair to H2A monoubiquitination dosage during neurogenesis.

Polycomb repressive complex 1 (PRC1) modifies chromatin through catalysis of histone H2A lysine 119 monoubiquitination (H2AK119ub1). RING1 and RNF2 interchangeably serve as the catalytic subunit within PRC1. Pathogenic missense variants in PRC1 core components reveal functions of these proteins that are obscured in knockout models.