Predictors of Left Atrial Thrombi for Subsequent Thromboembolisms: Risk Factors Derived from Echocardiography.

Background: Evidence regarding the management of left atrial thrombi (LATs) is limited.

Objectives: We aimed to investigate factors associated with subsequent thromboembolism in patients with LATs and explored potential management approaches.

Methods: This multicenter retrospective study consecutively enrolled patients who underwent morphological assessment of LAT using echocardiography.

Integrated Bioinformatic Analyses Reveal Thioredoxin as a Putative Marker of Cancer Stem Cells and Prognosis in Prostate Cancer.

Objectives: Prostate cancer stem cells (CSCs) play an important role in cancer cell survival, proliferation, metastasis, and recurrence; thus, removing CSCs is important for complete cancer removal. However, the mechanisms underlying CSC functions remain largely unknown, making it difficult to develop new anticancer drugs targeting CSCs. Herein, we aimed to identify novel factors that regulate stemness and predict prognosis.

Novel in vivo observations of luliconazole 5% nail solution for onychomycosis: An ultrastructural study.

Lesional nails of 10 patients with onychomycosis (tinea unguium) were investigated by transmission electron microscopy (TEM) to gain an insight into in vivo morphological changes of dermatophytes after application of a clinical dosage of topical luliconazole (LLCZ) 5% nail solution. In these cases, Trichophyton rubrum (T. rubrum) was identified in three cases and T.

Development of computer adaptive tests to assess the psychological status of individuals with an eating disorder or type 2 diabetes.

Background: Individuals with type 2 diabetes and eating disorders must change their eating behaviors, which are often influenced by psychological factors like depression and anxiety. To efficiently assess daily psychological status, the present study aimed to develop computerized adaptive tests (CAT) based on item response theory (IRT).

Methods: Individuals with depression, anxiety disorders, eating disorders, type 2 diabetes, and healthy persons participated in the study.

Comprehensive Search for Genes Involved in Thalidomide Teratogenicity Using Early Differentiation Models of Human Induced Pluripotent Stem Cells: Potential Applications in Reproductive and Developmental Toxicity Testing.

Developmental toxicity testing is essential to identify substances that may harm embryonic development. This study aimed to establish a protocol for evaluating developmental toxicity using human induced pluripotent stem cells (iPSCs) by analyzing cellular activity and gene expression changes. Two ICH S5(R3) positive substances, valproic acid (VPA), which is a substance previously detected as positive by other test methods, and thalidomide (Thalido), were examined during early trichoderm differentiation without fetal bovine serum.