Publications by authors named "T Hojyo-Tomoka"
Article Synopsis
- Actinic Prurigo (AP) is a skin condition that causes chronic itching, primarily affecting certain ethnic groups with specific genetic markers, but the role of dendritic cells in the skin has not been previously studied.
- The study aimed to examine the status of Langerhans Cells (LC), a type of dendritic cell, in the skin of AP patients by comparing affected and unaffected areas.
- Results showed a significant decrease in the number of Langerhans Cells in the lesional skin compared to non-lesional skin, indicating a possible link between LC frequency and the condition.
Background: Actinic prurigo (AP) is a photodermatosis with a restricted ethnic distribution, mainly affecting Mestizo women (mixed Indian and European). The lesions are polymorphic and include macules, papules, crusts, hyperpigmentation and lichenification. Thalidomide, an effective immunomodulatory drug, was first used successfully to treat AP in 1973.
View Article and Find Full Text PDFBackground: Pemphigus is an autoimmune disease characterized by intraepidermal blisters induced by pemphigus IgG. In addition to autoantibodies, molecular mechanisms involved in acantholysis remain largely unknown. For this reason, we address a possible role of the inflammatory cytokines IL-6 and TNFalpha in pemphigus lesions.
View Article and Find Full Text PDFBackground: Actinic prurigo (AP) is triggered by sun exposure. Its prevalence in Mexicans seems to be particularly high, which suggests a genetic susceptibility.
Objective: Our purpose was to determine the role of major histocompatibility complex (MHC) genes in the genetic susceptibility to AP.