Assessing Efficiency in a Static-Based 9-1-1 Ambulance Service: An Analysis of Operational Performance Metrics.

Objectives: This study sought to evaluate performance indicators to assist a static-based 9-1-1 agency in defining its response efficiency.

Methods: Initial assessment of three metrics-unit hour utilization (UHU), fractile response intervals, and level 0 frequency (occurrence when no ambulances are available to respond)-suggested the agency's response over its four coverage zones was inefficient, so an operational change was implemented: an ambulance was relocated from one service area to another to improve the overall response productivity. A 2-year retrospective analysis was performed to determine the impact ambulance relocation had on the three targeted measurements.

Themes for evaluating the quality of initiatives to engage patients and family caregivers in decision-making in healthcare systems: a scoping review.

Objective: To identify the key themes for evaluating the quality of initiatives to engage patients and family caregivers in decision-making across the organisation and system domains of healthcare systems.

Methods: We conducted a scoping review. Seven databases of journal articles were searched from their inception to June 2019.

Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitro.

Intraluminal thrombus formation precipitates conditions such as acute myocardial infarction and disturbs local blood flow resulting in areas of rapidly changing blood flow velocities and steep gradients of blood shear rate. Shear rate gradients are known to be pro-thrombotic with an important role for the shear-sensitive plasma protein von Willebrand factor (VWF). Here, we developed a single-chain antibody (scFv) that targets a shear gradient specific conformation of VWF to specifically inhibit platelet adhesion at sites of SRGs but not in areas of constant shear.

A kinetic model for redox-active film based biophotoelectrodes.

Redox-active films are advantageous matrices for the immobilization of photosynthetic proteins, due to their ability to mediate electron transfer as well as to achieve high catalyst loading on an electrode for efficient generation of electricity or solar fuels. A general challenge arises from various charge recombination pathways along the light-induced electron transfer chain from the electrode to the charge carriers for electricity production or to the final electron acceptors for solar fuel formation. Experimental methods based on current measurement or product quantification are often unable to discern between the contributions from the photocatalytic process and the detrimental effect of the short-circuiting reactions.

Thrombosis in diabetes: a shear flow effect?

Cardiovascular events are the major cause of morbidity and mortality in Type 2 diabetes (T2D). This condition is associated with heightened platelet reactivity, contributing to increased atherothrombotic risk. Indeed, individuals with diabetes respond inadequately to standard antiplatelet therapy.