Publications by authors named "T Hiwasa"
Article Synopsis
- Numerous antibody biomarkers exist for cancer and atherosclerosis-related diseases, highlighting the connections between conditions like acute ischemic stroke, cardiovascular disease, and diabetes mellitus.
- The study identifies KIAA0513 as a potential common biomarker linked to these diseases, showing higher serum antibody levels in patients compared to healthy individuals.
- The research suggests that serum anti-KIAA0513 antibody levels could effectively diagnose various conditions, indicating shared arterial changes associated with both atherosclerosis and cancer.
Article Synopsis
- This study explores the link between fumarate hydratase (FH) autoantibodies and gastric cancer to assess their potential as biomarkers.
- The analysis involved 116 gastric cancer patients and 96 healthy controls, revealing that serum FH autoantibody levels were significantly higher in cancer patients, even in early-stage cases.
- Low levels of these antibodies correlate with poorer outcomes, such as distant metastasis and overall survival, suggesting they could serve as important indicators for early diagnosis and prognosis in gastric cancer.
Inflammation is closely associated with cerebrovascular diseases, cardiovascular diseases, diabetes, and cancers, and it is accompanied by the development of autoantibodies in the early stage of inflammation-related diseases. Hence, it is meaningful to discover novel antibody biomarkers targeting inflammation-related diseases. In this study, Jumonji C-domain-containing 6 (JMJD6) was identified by the serological identification of antigens through recombinant cDNA expression cloning.
View Article and Find Full Text PDFGiven that esophageal cancer is highly malignant, the discovery of novel prognostic markers is eagerly awaited. We performed serological identification of antigens by recombinant cDNA expression cloning (SEREX) and identified SKI proto-oncogene protein and transmembrane p24 trafficking protein 5 (TMED5) as antigens recognized by serum IgG antibodies in patients with esophageal carcinoma. SKI and TMED5 proteins were expressed in Escherichia coli, purified by affinity chromatography, and used as antigens.
View Article and Find Full Text PDFBackground: At different stages of the disease, biomarkers can help to determine disease progression and recurrence and provide a personalized indicator of therapeutic effectiveness. The serological identification of antigens by recombinant cDNA expression cloning (SEREX) has identified five SEREX antigens.
Results: Compared with healthy donors, anti-FIRΔexon2 and anti-SOHLH antibodies (Abs) in the sera of patients with colorectal cancer (CRC) were markedly higher.