Publications by authors named "T Hilsabeck"

Article Synopsis
  • Individuals of the same species age at different rates due to factors such as genetics and environmental interactions, but even genetically identical organisms can show lifespan variation, suggesting deeper causes of aging.
  • Research on haploid yeast explored how metabolic pathways and their redundancies may influence lifespan differences, using a complex model encompassing over 1,100 genes and thousands of reactions and metabolites.
  • By testing various methods, including deep learning and principal component analysis, the study identified a core network of reactions connected to aging, revealing that specific metabolic pathways significantly impact lifespan variability.
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Article Synopsis
  • Dietary restriction (DR) can improve lifespan and healthspan, but individual responses depend on genetics, particularly metabolism-related variations.
  • The study analyzed data from Drosophila and human cohorts to understand how different genotypes respond to dietary changes, using computational methods like random forest modeling and Mendelian randomization.
  • Key findings include the identification of specific metabolites (like orotate and threonine) that affect lifespan and healthspan traits, suggesting potential therapeutic pathways for diet-based interventions.
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The National Ignition Facility produced the first nuclear fusion experiment demonstrating net positive energy gain on December 5, 2022. The x-ray streak camera that measures the bang time and burn-width from this landmark experiment had an electronic failure and did not record data. The CCD sensor was replaced with a radiation hardened CMOS sensor that has since demonstrated successful operation on repeat ignition shots.

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Inertial confinement fusion experiments taking place at the National Ignition Facility are generating ever increasing amounts of fusion energy, with the deuterium tritium fusion neutron yield growing a hundredfold over the past ten years. Strategies must be developed to mitigate this harsh environment's deleterious effects on the operation and the performance of the time-resolved x-ray imagers deployed in the National Ignition Facility target bay to record the dynamics of the implosions. We review the evolution of these imagers in recent years and detail some of the past and present efforts undertaken to maintain or improve the quality of the experimental data collected on high neutron yield experiments.

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An indirect-drive inertial fusion experiment on the National Ignition Facility was driven using 2.05 MJ of laser light at a wavelength of 351 nm and produced 3.1±0.

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