Publications by authors named "T Hildebrandt"
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multisystemic disease with a multifactorial pathogenesis involving dietary, environmental, and genetic factors. Previous mouse models suggested that circadian misalignment may additionally influence its development as it influences metabolism in diverse organs including the liver. Further, data from sleep questionnaires proved sleep-wake disruption in patients with MASLD.
View Article and Find Full Text PDFProgress Toward Genetic Rescue of the Northern White Rhinoceros ().
Annu Rev Anim Biosci
November 2024
The northern white rhinoceros (NWR) is functionally extinct, with only two nonreproductive females remaining. However, because of the foresight of scientists, cryopreserved cells and reproductive tissues may aid in the recovery of this species. An ambitious program of natural and artificial gamete and in vitro embryo generation was first outlined in 2015, and many of the proposed steps have been achieved.
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- Prevalence of HIV
- : Approximately 38.4 million people live with HIV globally, with a significant number (1.7 million) being children under 14, primarily in sub-Saharan Africa, where mother-to-child transmission is common and diagnoses are often delayed.
- Case Report
- : A 13-year-old boy from rural Gabon experienced repeated fever and fatigue for years, leading to multiple undiagnosed hospital visits. Ultimately, he was diagnosed with late-onset AIDS after serologic testing revealed HIV-1 infection.
- Importance of Early Detection
- : The case underlines the critical need for HIV testing in children and adolescents, especially in malaria-prone areas, as early diagnosis can significantly improve
Antiresorptive therapy in combination with radiation results in enhanced risk for necrosis and associated complicatifions.
Oral Surg Oral Med Oral Pathol Oral Radiol
January 2025
Article Synopsis
- Patients treated with both antiresorptive medication and radiotherapy in the head and neck are at increased risk for developing complications such as jaw necrosis, fractures, and recurrence of conditions.
- The study involved 17 patients who were compared to larger control groups, revealing significant differences in outcomes, with those receiving combined treatment facing higher risks.
- The findings suggest that the combination of these treatments leads to a four-fold increase in recurrence risk and a higher likelihood of serious complications compared to patients receiving just one type of treatment.
Advanced assisted reproduction technologies in endangered mammalian species.
Reprod Domest Anim
October 2024
A new synergistic approach of classical conservation strategies combined with advanced assisted reproduction technologies (aART) allows for protection and rescue of endangered keystone species at the brink of extinction, which can help to safeguard complex ecosystems. Reproduction biology and management in mammal species is not only challenging in regards to their diverging sizes, anatomy, and often unknown physiology; it also requires customized training or chemical restraint protocols for safe handling. Besides these general challenges, there are several new assisted reproduction techniques (ART) specifically tailored to critically endangered mammals.
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