Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1.

Somatic hypermutation (SHM) of Ig variable region (IgV) genes requires both IgV transcription and the enzyme activation-induced cytidine deaminase (AID). Identification of a cofactor responsible for the fact that IgV genes are much more sensitive to AID-induced mutagenesis than other genes is a key question in immunology. Here, we describe an essential role for a splice isoform of the prototypical serine/arginine-rich (SR) protein SRSF1, termed SRSF1-3, in AID-induced SHM in a DT40 chicken B-cell line.

A 15-year clinical comparative study of the cumulative survival rate of cast metal core and resin core restorations luted with adhesive resin cement.

Purpose: The aim of this study was to compare the core survival rates (CSRs) of cast metal versus resin core restorations luted with adhesive resin cement, as well as to determine the risk factors for core failure.

Materials And Methods: Nine hundred ninety-one patients (2,124 cores) who received either cast metal or resin cores luted with adhesive resin cement at the Fixed Prosthodontic Clinic of Okayama University Dental Hospital between April 1988 and December 1991 and whose structured clinical core record was filled appropriately comprised the study subjects. The clinical core record included information regarding patient age, sex, core restoration type, tooth location, tooth type, remaining coronal dentin, and root canal form.

[Dissection of the extracranial vertebral artery: a case report].

Spontaneous dissection of the vertebral artery is not a frequent occurrence in the vertebrobasilar system. The authors show a case with spontaneous dissection of the extracranial vertebral artery, which produced recurrent artery-to-artery embolism. The angiography revealed characteristic intimal flap.