Publications by authors named "T Hesse"
A Proof-of-Principle Study for δN Measurements of Aqueous Dissolved Nitrate With a Modified LC-IRMS Interface.
Rapid Commun Mass Spectrom
February 2025
Rationale: The analysis of nitrogen isotopes in aqueous dissolved nitrate is an effective method for identifying pollution sources and offers the potential to study the nitrogen cycle. However, the measurement of nitrogen isotope ratios of nitrate still requires extensive sample preparation or derivatization.
Methods: In this study, a modified commercially available liquid chromatography-isotope ratio mass spectrometer (LC-IRMS) interface is presented that enables automated measurement of δN signatures from nitrate by online reduction of nitrate in two consecutive steps.
Article Synopsis
- Gracilibacteria are a group of bacteria that are part of the candidate phyla radiation (CPR), characterized by small size and incomplete metabolic pathways, indicating a potential symbiotic lifestyle, and their roles in ecosystems, especially in groundwater, are still largely unknown.
- The study utilized metagenomic and metaproteomic analyses over a 12-day period at a cold-water geyser in Germany to observe the activity and genetic expression of Gracilibacteria, identifying multiple genomes and their interactions with other microbial communities.
- The findings revealed that Gracilibacteria possess genomic traits suggesting limited metabolic functions and a reliance on host organisms for survival, as indicated by a high number of genes related to cell interaction and motility.
Background: Eribulin, a halichondrin-class microtubule dynamics inhibitor, is a preferred treatment option for patients with advanced breast cancer who have been pretreated with an anthracycline and a taxane. Peripheral neuropathy (PN) is a common side effect of chemotherapies for breast cancer and other tumors. The Incidence and Resolution of Eribulin-Induced Peripheral Neuropathy (IRENE) noninterventional postauthorization safety study assessed the incidence and severity of PN in patients with breast cancer treated with eribulin.
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- Up to 30% of metastatic breast cancer patients develop brain metastases, which leads to poor prognosis and rarely long-term survival; thus, identifying factors that promote survival is crucial.
- An analysis of 2889 patients showed that long-term survivors (887 patients) were generally younger, had more HER2-positive tumors, and better overall health status at diagnosis.
- The median overall survival for long-term survivors was approximately 31 months, significantly higher than the cut-off of 15 months, indicating certain cancer characteristics and patient conditions improve survival outcomes.
Stable isotope analysis of individual compounds is emerging as a powerful tool to study nutrient origin and conversion in host-parasite systems. We measured the carbon isotope composition of amino acids and glucose in the cestode Schistocephalus solidus and in liver and muscle tissues of its second intermediate host, the three-spined stickleback (Gasterosteus aculeatus), over the course of 90 days in a controlled infection experiment. Similar linear regressions of δC values over time and low trophic fractionation of essential amino acids indicate that the parasite assimilates nutrients from sources closely connected to the liver metabolism of its host.
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