Perceived discrimination in patients with multiple sclerosis and depressive symptomatology.

Background: Multiple Sclerosis is the central nervous system's most common demyelinating disease and the second leading cause of neurological disability in young adults. Its natural development involves physical and cognitive impairment. Patients commonly perceive discrimination against them, regardless of its occurrence, accepting it as an inherent part of the disease.

Quality of life in patients with multiple sclerosis and its association with depressive symptoms and physical disability.

Objective: The aim of this work was to evaluate the quality of life of patients with multiple sclerosis and its association with depressive symptoms and physical health.

Method: A total of 117 patients clinically diagnosed with Multiple Sclerosis (MS) were studied. The MSQOL-54 scale was applied.

Molecular dynamics simulations reveal structural differences among wild-type NPC1 protein and its mutant forms.

is a 25-exon gene located on the long arm of chromosome 18q11.2 and encodes NPC1, a transmembrane protein comprising 1278 amino acid residues. Mutations in the gene can cause Niemann-Pick disease type C (NP-C), a rare autosomal-recessive neurovisceral disease.