Publications by authors named "T Hernandez-Caselles"
Article Synopsis
- The study investigates how polyamine levels during pregnancy are linked to maternal allergies and immune responses in newborns.
- Spermidine and spermine were found to be the main polyamines in both mothers and their newborns, with lower spermine levels associated with maternal allergic conditions, particularly allergic conjunctivitis.
- Higher levels of polyamines in cord blood correlated with an increased number of lymphocytes and reduced production of inflammatory and Th2-related cytokines, suggesting a potential protective effect against allergies in infants.
Elevated plasma levels of extracellular vesicles have been associated with impaired placentation, angiogenesis imbalance, intravascular inflammation, and endothelial dysfunction in women with preeclampsia, thus suggesting that circulating vesicles may be a good therapeutic target for the treatment of the disease. Recently, statins have been considered a potential treatment for the prevention of preeclampsia because of their pleiotropic effects, including the improvement of endothelial dysfunction and inhibition of inflammatory responses. However, the effects of these drugs on circulating vesicles concentration in women at risk of preeclampsia have not been established.
View Article and Find Full Text PDFBackground And Purpose: A high number of intratumoural infiltrating natural killer (NK) cells is associated with better survival in several types of cancer, constituting an important first line of defence against tumours. Hypoxia in the core of solid tumours induces cellular stress and ATP release into the extracellular space where it triggers purinergic receptor activation on tumour-associated immune cells. The aim of this study was to assess whether activation of the purinergic receptor P2X7 by extracellular ATP plays a role in the NK cells antitumour activity.
View Article and Find Full Text PDFBackground: Immune signatures at birth could be associated with clinical outcomes and will improve our understanding of immunity prenatal programming.
Methods: Data come from 235 newborns from the cohort study NELA. Production of cytokines was determined using Luminex technology.