Rate of response to immune checkpoint inhibitor therapy in patients with conjunctival melanoma.

Our primary objective was to estimate the overall response rate to immune checkpoint inhibitors (ICIs) in patients with locally advanced, multiply recurrent, or metastatic conjunctival melanoma treated with ICIs. A retrospective review of all consecutive conjunctival melanoma patients who were treated with ICI between October 2017 and January 2024 was carried out. The study included 16 patients with a median age of 66 years.

Adverse event assessment in a parenting programme: experiences from a multisite randomised controlled trial.

Background: Clinicians and researchers should consider the expected benefits and potential harms of an intervention. Parenting programmes are a widely used evidence-based intervention for child behaviour problems. However, few data are available on potential negative effects.

Giving Back What the Patient Brings: On Winnicott's "Mirror-Role of Mother and Family in Child Development".

The author offers a creative reading of Winnicott's (1967) "Mirror-role of mother and family in child development." Winnicott presents the idea that a pivotal experience in the process of the infant's coming into being as himself is the mother's communicating to the infant, by the look in her eyes, what she sees there when she looks at him. In the absence of the experience of being seen, the infant's capacity to feel real and alive atrophies.

Rethinking the concepts of the unconscious and analytic time.

The author proposes ways of rethinking the concepts of the unconscious and time in the analytic setting, including the very existence of the unconscious. Freud (1915) stated that the success psychoanalytic thinking has in making inferences about the patient's unconscious makes the existence of the unconscious "incontrovertible." The author submits that this success does not establish the existence of the unconscious; rather, the inferences we think we make about the unconscious are inferences about consciousness itself - the totality of our experiences of thinking, feeling, sensing, observing, and communicating with ourselves.

Transformations at the Dawn of Verbal Language.

In this essay the author describes some of the transformations that occur as one moves from preverbal functioning to verbally symbolic language. In preverbal experience, there is a direct connection between the sign and what is signified. An infant or child signifies displeasure by throwing his food or other objects to the floor.