Publications by authors named "T Hawro"
Mortality in adult patients with chronic spontaneous urticaria: A real-world cohort study.
J Allergy Clin Immunol
December 2024
Background: Chronic spontaneous urticaria (CSU), a common and debilitating disease, is widely held not to be life limiting, but the mortality of CSU has not been investigated.
Objective: We sought to assess all-cause mortality in patients with CSU, risk for comorbidities that are leading causes of death, and impact of guideline-recommended urticaria treatments on mortality rates.
Methods: This was a retrospective population-based cohort study of electronic health records of 272,190 adult patients with CSU and 12,728,913 controls without urticaria from the US collaborative network TriNetX.
The Mastocytosis Control Test: A Patient-Reported Outcome Measure Assessing Disease Control.
J Allergy Clin Immunol Pract
December 2024
Background: Mastocytosis is characterized by expanding neoplastic mast cells in organs such as the skin, bone marrow, and gastrointestinal tract. The release of mast cell mediators triggers cutaneous, gastrointestinal, and other symptoms. Currently, no validated mastocytosis-specific patient-reported outcome measure (PROM) exists to assess disease control.
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- Palmoplantar pustular psoriasis (PPPP) is a chronic skin condition that causes pustules on the palms and soles, affecting patients' lives and requiring better treatment options.
- * Researchers assessed the effectiveness and safety of deucravacitinib, a new oral medication, by analyzing five patients' responses over 16 weeks.
- * Results showed mixed initial reactions, with some patients improving and manageable side effects, but further studies with larger groups are needed to fully evaluate deucravacitinib's potential in treating PPPP.
Patients with primary cutaneous T-cell lymphoma (CTCL) often experience severe and difficult-to-treat pruritus that negatively affects their quality of life (QoL). However, the mechanisms of pruritus in CTCL, including mycosis fungoides (MF), remain largely unknown, and detailed characteristics of CTCL-associated pruritus is not fully elucidated. To characterize pruritus in CTCL, cutaneous B-cell lymphoma (CBCL), and large plaque parapsoriasis (LPP), and to identify potential itch mediators involved in the pathogenesis of pruritus in CTCL patients.
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- A significant percentage (31.2%) of patients with chronic spontaneous urticaria (CSU) experience non-skin-related symptoms (NSRS) like recurrent fever, joint/bone/muscle pain, and malaise.
- These NSRS are linked to various trigger factors such as food and infections, as well as clinical characteristics like sleep disturbances and elevated inflammation markers.
- Patients with NSRS tend to have worse disease activity, longer duration of CSU, lower quality of life, and a higher likelihood of poor control over their symptoms, highlighting the need for improved management strategies.