Publications by authors named "T Hargreaves"
Aims: Previous neuroimaging research in alcohol use disorder (AUD) has found altered functional connectivity in the brain's salience, default mode, and central executive (CEN) networks (i.e. the triple network model), though their specific associations with AUD severity and heavy drinking remains unclear.
View Article and Find Full Text PDFAlcohol use disorder is associated with overvaluation of alcohol relative to other rewards, in part due to dynamic increases in value in response to alcohol-related cues. In a neuroeconomic framework, alcohol cues increase behavioral economic demand for alcohol, but the neural correlates these cue effects are unknown. This functional magnetic resonance imaging study combined a neuroeconomic alcohol purchase task with an alcohol cue exposure in 72 heavy drinkers with established sensitivity to alcohol cues (51 % female; mean age=33.
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- - The study investigates how resting state functional connectivity (rsFC) in the brain may predict responses to brief interventions for alcohol use disorder (AUD) in individuals scanned via fMRI before treatment.
- - Forty-six individuals with AUD participated, and positive responses were defined as a decrease in alcohol consumption at a 3-month follow-up, with rsFC analyzed across different brain networks.
- - Findings revealed that effective responders exhibited different patterns of rsFC in specific brain regions compared to non-responders, suggesting that these connectivity patterns could serve as neurobiological indicators for predicting treatment outcomes.
Large proportions of smokers are unsuccessful in evidence-based smoking cessation treatment and identifying prognostic predictors may inform improvements in treatment. Steep discounting of delayed rewards (delay discounting) is a robust predictor of poor smoking cessation outcome, but the underlying neural predictors have not been investigated. Forty-one treatment-seeking adult smokers completed a functional magnetic resonance imaging (fMRI) delay discounting paradigm prior to initiating a 9-week smoking cessation treatment protocol.
View Article and Find Full Text PDFAim: Robust evidence suggests that depression, and risk for depression, are associated with the generation of stressful life events. This tendency to generate stress may be genetically determined. This systematic review aimed to identify specific molecular genetic markers associated with the generation of interpersonal stressful life events, at least in part dependent on individuals' behavior.
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