Publications by authors named "T Hamana"
Purpose Of Review: Plaque erosion is the second leading cause of coronary thrombosis following plaque rupture and represents a key pathophysiological process underlying acute coronary syndromes that can culminate in sudden coronary death. While the precise mechanisms and risk factors driving plaque rupture are well-established, those for erosion have only recently been explored. This review summarizes current literature on the characteristics and risk factors favoring plaque erosion.
View Article and Find Full Text PDFAtrial fibrillation (AF) is strongly associated with strokes, heart failure, and increased mortality. This study aims to identify the monocyte-macrophage heterogeneity and interactions of these cells with non-immune cells, and to identify functional biomarkers in patients with AF. Therefore, we assess the single cell landscape of left atria (LA), using a combination of single cell and nucleus RNA-seq.
View Article and Find Full Text PDFArticle Synopsis
- Optical coherence tomography (OCT) is used to identify dangerous plaques in patients with acute coronary syndrome (ACS), but manual analysis has its limitations.
- This study developed a deep-learning model using convolutional neural networks (CNN) and transformers to automatically predict the prognosis of ACS patients from OCT images after they underwent percutaneous coronary intervention (PCI).
- The deep-learning model showed superior predictive performance for target vessel failure compared to traditional models, indicating that it can effectively analyze OCT images as well as or better than human observers.
Background: Proprotein convertase subtilisin/kexin type 9 inhibitors stabilize vulnerable plaque, reducing cardiovascular events. However, manual optical coherence tomography (OCT) analysis of drug efficacy is challenging because of signal attenuation within lipid plaques.
Methods And Results: Twenty-four patients with thin-cap fibroatheroma were prospectively enrolled and randomized to receive alirocumab (75 mg every 2 weeks) plus rosuvastatin (10 mg/day) or rosuvastatin (10 mg/day) alone.
Clinical significance and biological role of claudin-1 in oral squamous cell carcinoma cells.
Oral Surg Oral Med Oral Pathol Oral Radiol
January 2025
Objectives: Claudin (CLD), a major component of tight junctions, is a four-transmembrane protein, and 24 subtypes have been reported in humans. CLD expression is highly tissue-specific; CLD1 has been reported to be expressed in the skin and mucosa. There have been few reports on CLD1 expression and its function in oral cancer.
View Article and Find Full Text PDF