Publications by authors named "T Hamajima"
Beam-divergence characteristics of single negative ion beamlet have been experimentally investigated with a superimposition of a controlled perturbation of a radio frequency wave (RF) field in a filament-arc discharge negative ion source. Oscillations of a negative-ion beamlet width and axis responding to the RF perturbation were observed, which may be a cause of the larger beam divergence angle of the RF negative ion source for ITER. It is pointed out that the oscillation of the beamlet width depends on the perveance and on an RF frequency such that the oscillation is suppressed at perveance-matched conditions and at low RF frequency.
View Article and Find Full Text PDFIntroduction: Precocious puberty (PP), which is sometimes divided into gonadotropin-dependent or gonadotropin-independent PP, is a pathological condition characterized by premature secretion of gonadal steroids resulting in the early development of secondary sexual characteristics. Girls younger than 6 years with idiopathic gonadotropin-dependent PP (referred to as central PP or CPP) who receive gonadotropin-releasing hormone analog (GnRHa) therapy experience an increase in their adult height (AH) in contrast to girls who are aged 6 years or more, who show no consistent pattern of increase even with GnRHa therapy.
Methods: In total, 133 girls aged 6 years or more who visited any one of the seven study centers between April 2000 and March 2020 and who met the diagnostic criteria for PP in Japan were retrospectively examined.
Article Synopsis
- Burosumab is a new medication designed for treating disorders related to hereditary fibroblast growth factor 23 (FGF23), specifically hypophosphatemia.
- An 11-year-old girl with McCune-Albright syndrome suffered from low phosphate levels and multiple bone lesions due to excess FGF23, but her condition improved significantly with burosumab treatment.
- This case marks the first instance of burosumab improving bone lesions in a patient with McCune-Albright syndrome, highlighting its potential therapeutic benefits.
Article Synopsis
- Achondroplasia (ACH) is a genetic condition leading to short stature and distinctive physical features, with a high complication rate observed in young patients.
- A study reviewing medical records of Japanese children with ACH under 5 years highlighted that 89.2% had complications, and a majority required surgical interventions.
- Growth hormone treatment initiated at age 3 resulted in significant height increases compared to untreated patients, emphasizing the importance of early diagnosis and monitoring for effective management.
Central congenital hypothyroidism (CH) can occur as an isolated deficiency or as part of combined pituitary hormone deficiency. Unlike primary CH, central CH cannot be detected by newborn screening (NBS) using dry filter paper blood TSH levels, and early diagnosis remains challenging. In this study, the clinical and genetic backgrounds of patients with isolated central CH were determined through a questionnaire-based survey among members of the Japanese Society for Pediatric Endocrinology.
View Article and Find Full Text PDF