Publications by authors named "T Hachenberg"

Purpose Of The Review: The mediastinal mass syndrome (MMS) can occur after induction of anesthesia, intraoperatively or even days after the surgical procedure. The focus of this review is on the management of pediatric and adult patients with a significant mediastinal mass.

Recent Findings: The age distribution of patients with mediastinal lesions suggests a bimodal shape, with an increased incidence among children under 10 years old and adults aged 60-70 years old.

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Anasthesiol Intensivmed Notfallmed Schmerzther

July 2024

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Background: High-frequency jet ventilation (HFJV) is used in pneumological endoscopy for rigid, diagnostic, and therapeutic bronchoscopies. It is unclear to what extent the unobstructed flow of respiratory gas from the patient's lungs causes microbial contamination of the surrounding air.

Material And Methods: After the start of the HFJV (15 min) in 16 rigid bronchoscopies, airborne pathogen measurements were taken directly at the distal endoscope outlet, at examiner height (40 cm above the endoscope outlet), at a 2 m distance from the endoscope in the room and at the supply air outlet of the examination room using an RCS air sampler.

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Article Synopsis
  • Early life microbial infections pose challenges to the developing immune system, and the study examines how T-helper cell responses vary between age groups and pathogens, particularly in the context of the SARS-CoV-2 pandemic.* -
  • The research highlights that T-cells responding to Staphylococcus species differentiate into Th1-type cells, while T-cells activated by Bifidobacterium longum infantis show a suppressive effect on Staphylococcus-specific T-helper cells through mechanisms like increased IL-10 production.* -
  • Bifidobacterium's ability to modulate immune responses may play a role in reducing harmful effects in severely ill COVID-19 patients, suggesting that tailored interventions based on age and immune characteristics could improve infection
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