Advancing PFAS characterization: Enhancing the total oxidizable precursor assay with improved sample processing and UV activation.

Per- and polyfluoroalkyl substances (PFAS) encompass over 9000 chemicals utilized in various industrial and commercial applications. However, the quantification of PFAS using standard commercial analytical methods is currently limited to <50 selected compounds. To address this issue, the total oxidizable precursor (TOP) assay was developed, allowing for the oxidative conversion of previously undetectable PFAS precursors into measurable PFAS.

[Timing of gonadectomy in patients with complete androgen insensitivity syndrome].

Complete androgen insensitivity syndrome is the most frequent cause of disorder of sexual development in 46 XY patients. It is caused by mutations of the AR gene coding for the androgen receptor. Transmission is X-linked and mutations are most of the time inherited.

Neuron loss and shrinkage in the amygdala in Alzheimer's disease.

Total neuron numbers in the amygdala and in eight of its subnuclei were determined in 9 cases of Alzheimer's disease (AD) and in 6 age-matched controls (AMC). Total neuron numbers were obtained using the fractionator. A neuron loss of 56.

Loss of collagen from experimental intestinal anastomoses: early events.

Collagen lysis, which always occurs to some extent in the wound area, is thought to be the underlying cause for breakdown of intestinal anastomoses. Therefore, we have studied the loss of collagen around ileal and colonic anastomoses in New Zealand White rabbits during the first 48 hr after operation. In the ileum, significant lysis of collagen in the anastomotic area, as represented by a decreased level of hydroxyproline, occurs from 12 hr postoperatively onward.