Publications by authors named "T H Scholl"
Fluorine-19 (F) MRI has become an established tool for in vivo cell tracking following ex vivo or in vivo labelling of various cell types with F perfluorocarbons (PFCs). Here, we developed and evaluated novel mouse-specific radiofrequency (RF) hardware for improved dual H anatomical imaging and deep tissue F MR detection of PFCs. Three linearly polarized birdcage RF coils were constructed-a dual-frequency H/F coil, and a pair of single-frequency H and F coils, designed to be used sequentially.
View Article and Find Full Text PDFObjective: Previous retrospective studies have reported vigabatrin-associated brain abnormalities on magnetic resonance imaging (VABAM), although clinical impact is unknown. We evaluated the association between vigabatrin and predefined brain magnetic resonance imaging (MRI) changes in a large homogenous tuberous sclerosis complex (TSC) cohort and assessed to what extent VABAM-related symptoms were reported in TSC infants.
Methods: The Dutch TSC Registry and the EPISTOP cohort provided retrospective and prospective data from 80 TSC patients treated with vigabatrin (VGB) before the age of 2 years and 23 TSC patients without VGB.
Background: Sodium (Na) MRI of prostate cancer (PCa) is a novel but underdocumented technique conventionally acquired using an endorectal coil. These endorectal coils are associated with challenges (e.g.
View Article and Find Full Text PDFHistopathological assessment of tissue samples after prolonged formalin fixation has been described previously, but currently there is only limited knowledge regarding the feasibility of molecular pathology on such tissue. In this pilot study, we tested routine molecular pathology methods (DNA isolation, DNA pyrosequencing/next-generation sequencing, DNA methylation analysis, RT-PCR, clonality analysis and fluorescence in situ hybridization) on tissue samples from 11 tumor entities as well as non-neoplastic brain tissue from 43 body donors during the gross anatomy course at Ulm University (winter semester 2019/20 and 2020/21). The mean post mortem interval until fixation was 2.
View Article and Find Full Text PDFArticle Synopsis
- This study focuses on the development of HER2-targeted chimeric antigen receptor natural killer (CAR-NK) cells as a potential therapy for ovarian cancer, offering a less complex and more cost-effective alternative to traditional CAR T cell therapies.
- CAR-NK cells were genetically modified to express both a HER2-targeted CAR and a PET reporter gene, allowing for better tracking and imaging of these immune cells after administration.
- Experimental results demonstrated that CAR-NK cells were more effective in killing cancer cells, reducing tumor size and improving survival in mice, while also allowing for successful monitoring through bioluminescence and PET imaging techniques.