Publications by authors named "T H Patricia Tai"
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated cancer, and immune checkpoint inhibitors (ICIs) have shown efficacy in its treatment. The combination of chemotherapy and ICIs represents a new trend in the standard care for metastatic NPC. In this study, we aim to clarify the immune cell profile and related prognostic factors in the ICI-based treatment of metastatic NPC.
View Article and Find Full Text PDFFew cases of tenofovir resistance have been reported, and the appropriate treatment for such cases remains unclear. We aimed to share a case of a chronic hepatitis B mono-infected patient with potential tenofovir resistance who required combined lamivudine and tenofovir therapy to achieve adequate viral suppression. The patient's viral load (plasma) was monitored using the cobas® hepatitis B virus Test on the cobas® 6800 system.
View Article and Find Full Text PDFBackground: Prompt primary percutaneous coronary intervention (pPCI) is crucial for the prognosis and reduction of myocardial damage in ST-segment elevation myocardial infarction (STEMI) patients. The Coronavirus Disease 2019 (COVID-19) pandemic had multifaceted impacts on healthcare. This study assessed the effects of the pandemic on pPCI procedures and clinical outcomes in emergency STEMI patients.
View Article and Find Full Text PDFArticle Synopsis
- Effective blood sampling times for vancomycin AUC estimation have not been clearly defined, prompting this study to explore different sampling times during dosing intervals.
- Six participants were studied after receiving intravenous vancomycin, with AUC estimated using various software and models, assessing accuracy through bias and imprecision.
- The study identified optimal blood sampling times of 2.5 and 5.5 hours post-injection for certain software, suggesting improved therapeutic drug monitoring could result from standardized sampling times.
Article Synopsis
- Utilisation of health services for mood and anxiety disorders in China is low and often delayed, despite the availability of effective treatments.
- The study analyzed data from the China Mental Health Survey, identifying 3,075 patients out of 32,552 surveyed, with only 15.5% seeking any health care, and even fewer (4.8%) pursuing specialized mental health services.
- Key findings indicated that delays in seeking care were significant, particularly for depressive (1.0 years), bipolar (1.9 years), and anxiety disorders (10.0 years), with younger patients and those with comorbidities more likely to seek help.
- The study suggests that national strategies are essential for increasing health care utilization among individuals with mental health