[Toxicological evaluation of biopreparations on the basis of nitrogen-fixing bacteria].

A comparative analysis of results of toxicological research of microbiological preparations on the basis of different species of nitrogen-fixing microorganisms of Azotobacter, Agrobacterium, Azospirillum general and pathogenic properties of strains-producers has been carried out. A possibility to improve methodical principles of toxicological estimation and hygienic regulation of associative nitrogen-fixing microorganisms-producers and preparations on their basis in the industrial objects and environment is substantiated. The paper is presented in Ukrainian.

[Investigation of the safety of microbial biotechnological products and their hygienic regulation].

Peculiarities of influence of microbial preparations based on microorganisms of different taxonomic groups on the warm-blooded organisms are considered, that is necessary to take into account when developing the strategy of toxico-hygienic studying of these preparations and when substanting hygienic standards in industrial objects and in the environment. The possibility to simplify the methodical scheme of the toxicological estimation and the hygienic regulation of microbial preparations on the basis of soil nitrogen-fixing microorganisms is discussed.

[The insecto-fungicidal preparation, gaupsin, isolated from Pseudomonas aureofaciens strains].

The integrated insectofungicidal preparation Gaupsin was developed on the basis of the Pseudomonas aureofaciens strains UKM V-111, which is active against bacterial and fungal phytopathogens, and UKM V-306, active against codling moth larvae. Gaupsin is an effective means for protection of orchards against moths and fungi. A method for production of Gaupsin in the liquid form with a titer of not less than 1 x 10(10) cells/ml under aeration conditions was elaborated.

[A toxicological evaluation of an Agrobacterium radiobacter-based biological fertilizer].

Pathogenic properties (for warm-blooded organisms) of the industrial strain Agrobacterium radiobacter (strain 204) and toxicity of biofertilizer on its base--rhizoagrin--have been studied. It is established that the studied microorganisms are avirulent, nontoxic, nontoxicogenic and may be recommended for making biopreparations. The preparation rhizoagrin is not toxic for warm-blooded animals and may be used as an alternative of chemical mineral fertilizers.