Fixed dosing of alpelisib for children with vascular anomalies: Can we do better?

Severe forms of vascular malformations (VM) can highly impact patients' quality of life and lead to life-threatening organ dysfunction. Numerous VM are caused by somatic activating mutations in the PI3K/AKT/mTOR signalling pathway. Alpelisib, a PIK3CA inhibitor was recently FDA-approved for paediatric PIK3CA-related overgrowth syndrome (PROS).

Diversity of Mycotoxins in Stored Paddy Rice: Contamination Patterns in the Mekong Delta, Vietnam.

Rice ( L.) is the most important food in Vietnam. However, rice is often lost in post-harvest due to fungal growth and mycotoxins contamination.

Optimizing adsorption and photocatalysis for tetracycline and sulfamethoxazole removal: the role of Ag and NH in Bi-MOF derivatives.

This study focuses on the synthesis, characterization, and evaluation of the photocatalytic efficiency of bismuth-based metal-organic frameworks (Bi-MOFs) and their derivatives, specifically Ag/Bi-MOF and NH /Ag/Bi-MOF, in the degradation of tetracycline (TC) and sulfamethoxazole (SMX) under visible light irradiation. Bi-MOFs are promising photocatalysts due to their large surface area, tunable porosity, and unique electronic properties that are favorable for visible light absorption. In this study, Bi-MOFs were synthesized using a solvothermal method, with the incorporation of silver (Ag) and ammonium (NH ) ions to enhance their photocatalytic performance.

Patient Experience Regarding Medication-Related Information Received in a Rural Private Polyclinic Setting in Vietnam.

Inadequate provision of medication-related information can lead to nonadherence to treatment. This study aims to investigate patient satisfaction regarding medication-related information provided by healthcare professionals and to identify factors associated with patient experience regarding information. A cross-sectional descriptive study was conducted in October 2023 among 400 patients at a rural private polyclinic in Ben Tre, Vietnam by using a self-administered questionnaire.

Comparing three summary indices to assess diet quality of Canadian children: a call for consensus.

Purpose: The Healthy Eating Index-Canada 2015 (HEI-C 2015), Diet Quality Index-International (DQI-I), and Healthy Eating Food Index 2019 (HEFI-2019) are commonly used to summarize the quality of Canadian diets. This paper sought to compare these three diet quality indices with respect to their ability to capture diets of different quality in Canadian children and to discriminate between population subgroups.

Methods: Data were collected in school-based surveys from grade 4-6 students (9-12 years old) in western Canada through 24-h dietary recall in 2016 ( = 336), 2018 ( = 454), and 2020/2021 ( = 909).