Causal relationship between psoriasis and sudden deafness: a Mendelian randomization study.

Objective: This study aims to investigate the genetic link between psoriasis and sudden sensorineural hearing loss (SSNHL).

Methods: From a genetic standpoint, this study further highlighted the connection between psoriasis and SSNHL. Single nucleotide polymorphisms (SNPs) connected to SSNHL could be found using a genome-wide association study from the IEU OpenGWAS project website.

Soil cadmium pollution elicits sex-specific plant volatile emissions in response to insect herbivory in eastern cottonwood Populus deltoides.

Soil heavy metal pollution is a major abiotic stressor frequently encountered by plants in conjunction with other biotic stresses like insect herbivory. Yet, it remains largely unexplored how soil metal pollution and insect herbivory act together to influence emissions of plant volatile organic compounds (VOCs), which mediate multiple ecological functions and play crucial roles in atmospheric processes. Here, we assessed the individual and combined effects of soil cadium (Cd) pollution and insect herbivory by Clostera anachoreta on VOC emissions from the seedlings of eastern cottonwood Populus deltoides, and whether these effects depend on plant sex.

Comparison of short-term surgical outcomes between high and low tie ligation of the inferior mesenteric artery in robotic rectal cancer surgery: a propensity score matching analysis.

Robotic surgery is extensively used for rectal cancer treatment. Nonetheless, studies on whether to preserve the left colonic artery (LCA) during robotic rectal cancer surgery to reduce complications remain scarce and controversial. This study compared short-term outcomes of high tie (HT) and low tie (LT) ligation of the inferior mesenteric artery in 455 patients undergoing robotic rectal cancer surgery between May 2018 and July 2022.

Alzheimer's disease and diabetes-associated cognitive dysfunction: the microglia link?

Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques and the aggregation of tau protein, resulting in intense memory loss and dementia. Diabetes-associated cognitive dysfunction (DACD) is a complication of diabetes mellitus, which is associated with decreased cognitive function and impaired memory. A growing body of literature emphasize the involvement of microglia in AD and DACD.

Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway.

The lack of knowledge about the mechanism of hyperoxia-induced intestinal injury has attracted considerable attention, due to the potential for this condition to cause neonatal complications. This study aimed to explore the relationship between hyperoxia-induced oxidative damage and ferroptosis in intestinal tissue and investigate the mechanism by which hyperoxia regulates inflammation through ferroptosis. The study systematically evaluated the effects of hyperoxia on oxidative stress, mitochondrial damage, ferroptosis, and inflammation of intestinal epithelial cells both in vitro and in vivo.