Predicting early stage lung cancer recurrence and survival from combined tumor motion amplitude and radiomics on free-breathing 4D-CT.

Background: Cancer control outcomes of lung cancer are hypothesized to be affected by several confounding factors, including tumor heterogeneity and patient history, which have been hypothesized to mitigate the dose delivery effectiveness when treated with radiation therapy. Providing an accurate predictive model to identify patients at risk would enable tailored follow-up strategies during treatment.

Purpose: Our goal is to demonstrate the added prognostic value of including tumor displacement amplitude in a predictive model that combines clinical features and computed tomography (CT) radiomics for 2-year recurrence and survival in non-small-cell lung cancer (NSCLC) patients treated with curative-intent stereotactic body radiation therapy.

Climate change policies reduce air pollution and increase physical activity: Benefits, costs, inequalities, and indoor exposures.

The burden of diseases attributable to air pollution is comparable to those of global health risks such as unhealthy diets and tobacco smoking, with many air pollution sources also emitting climate heating gases. In this UK study we estimated the co-benefits of Net Zero (NZ) climate policy on the health benefits of air pollution reduction, increased active travel, outdoor exposure inequalities and indoor air pollution changes. The study focused on two of the largest UK sources, road transport and building heating, with comparisons made between NZ and UK existing policy, referred to as Business as Usual (BAU).

New Shikimic Acid Derivatives From the Marine-Derived Actinomycete Streptomyces sp. G666 and Their Antimicrobial Activities.

Analysis of an antimicrobial extract from the agar-based culture of the marine-derived actinomycete Streptomyces sp. G666 led to the isolation of three new shikimic acid derivatives, streptomine A-C (1-3), along with five known compounds (4-8). Their structures were established by their spectral data analyses, including MS and NMR.

The Effectiveness of Afatinib as First-Line Treatment in Vietnamese Patients With EGFR-Mutant Non-Small Cell Lung Cancer and Brain Metastases.

Introduction: The role of afatinib in the first-line treatment of EGFR-mutant advanced non-small cell lung cancer (NSCLC) patients has been proven through clinical trials and real-world studies. However, additional data on the effectiveness of afatinib in patients with brain metastases are lacking.

Methods: EGFR-mutant NSCLC patients with brain metastases were retrospectively reviewed across nine cancer centers in Vietnam from April 1, 2018 to June 1, 2022.

Changes in retail cigarette price after tax increase: Findings from the 2018-2020 ITC Vietnam surveys.

Introduction: No longitudinal study has investigated the impact of cigarette tax increases on retail prices in Vietnam. This study aims to describe changes in the purchase price of cigarettes following an excise tax increase from 70% to 75% in January 2019.

Methods: Data were collected from people who currently smoke cigarettes in the longitudinal ITC Vietnam surveys: 1870 participants in Wave 1 (pre-increase), 1564 in Wave 2 (post-increase), and 1308 in Wave 3 (post-increase).