Publications by authors named "T H Inge"
Background: Metabolic and bariatric surgery is a safe and effective treatment strategy for severe childhood obesity, affecting 10% of US adolescents.
Objectives: This prospective observational study addresses knowledge gaps related to changes in weight, cardiometabolic risk, and weight-related quality of life (WRQOL) in adolescents 10 years after laparoscopic adjustable gastric band (LAGB) insertion.
Setting: Five Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) US centers.
Objective: To identify factors associated with incident alcohol consumption, hazardous drinking, alcohol-related problems, and substance use up to 8 years following metabolic and bariatric surgery (MBS) during adolescence.
Background: In this cohort, nearly half of those who underwent MBS as adolescents screened positive for alcohol use disorder, symptoms of alcohol-related harm, or alcohol-related problems within 8 years post-surgery. Moreover, persistent or heavy marijuana use following MBS during adolescence is higher than national data.
Article Synopsis
- The study investigates the link between per- and polyfluoroalkyl substances (PFAS), specifically perfluoroheptanoic acid (PFHpA), and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in obese adolescents.
- Results show that higher PFHpA plasma concentrations correlate with increased MASLD risk and that PFHpA disrupts liver metabolism, particularly lipid metabolism.
- The research also introduces a novel approach to identify individuals at high risk for PFHpA-induced MASLD and suggests potential early intervention strategies based on molecular signatures.