Examining Whether Exercise Preference and Tolerance Moderate the Within-Subject Association Between Physical Activity Intention and Next-Day Moderate to Vigorous Physical Activity.

Background: Physical activity (PA) intentions may predict future PA engagement, such that when intentions for PA are strong, an individual may be more likely to engage in PA compared with when intentions for PA are weak. However, intentions do not always translate into behavior, a phenomenon known as the intention-behavior gap. Individual differences in exercise preference (predisposition for high-intensity exercise) and tolerance (ability to continue exercising at higher intensity) may explain this gap.

Transient upregulation of procaspase-3 during oligodendrocyte fate decisions.

Oligodendrocytes are generated throughout life and in neurodegenerative conditions from brain resident oligodendrocyte precursor cells (OPCs). The transition from OPC to oligodendrocyte involves a complex cascade of molecular and morphological states that position the cell to make a fate decision to integrate as a myelinating oligodendrocyte or die through apoptosis. Oligodendrocyte maturation impacts the cell death mechanisms that occur in degenerative conditions, but it is unclear if and how the cell death machinery changes as OPCs transition into oligodendrocytes.

Optimization Methodology of Polar Direct-Drive Illumination for the National Ignition Facility.

Improved laser illumination uniformity drives shocks and implosions to create more extreme high energy density environments. Predominantly, the geometry of experiments that can be performed is dictated by the layout of beams at laser facilities, limiting interfacility and multiscale investigations. This Letter presents the first automated, algorithmic approach for generating illumination configurations for high energy density experiments.

Alcohol and cannabis use associated with cardiometabolic biomarkers among "All of Us" cancer survivors.

Background: Cancer survivors are at increased risk for cardiometabolic comorbidities following cancer treatment which may be further exacerbated by cannabis and alcohol use. We aimed to examine the direct relationships of cannabis, alcohol, and the co-use of both substances with cardiometabolic risk factors and to explore disparities by race/ethnicity and sex.

Methods: Cross-sectional data were extracted from adult cancer survivors in the "All of Us" from 2018-2022.