Publications by authors named "T H C Sasahara"
Background: The giant anteater (Myrmecophaga tridactyla) is a toothless mammal that feeds mainly on termites and ants. Therefore, like other toothless mammals, this species has morphological and physiological adaptations of the salivary glands related to eating habits. Saliva is essential for the health of the oral cavity, chewing and lubrication of the mouth and it is constituted by an aqueous fluid containing electrolytes, enzymes, and glycoproteins which play an important role in modulating the oral microbiota.
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- Many new nurses experience stress due to environmental changes, which can lead to resignations, highlighting the need for strategies to retain them, especially in light of Japan's nursing shortage.
- A study analyzed the characteristics of 353 newly graduated nurses to identify factors related to early resignation, comparing traits of those who left within a year to those who stayed.
- Results indicated that high trait anxiety and low nurse orientation are significant predictors of early resignation, suggesting that targeted support could help retain these nurses.
A Comprehensive Review on Phage Therapy and Phage-Based Drug Development.
Antibiotics (Basel)
September 2024
Article Synopsis
- Phage therapy is gaining attention as a potential solution for treating infections caused by multidrug-resistant bacteria, leveraging naturally occurring viruses called bacteriophages.
- The review covers the historical background, recent advancements, and various applications of phages, including their use in medical fields like vaccine development and cancer treatment.
- Despite its advantages, phage therapy still faces obstacles such as maintaining phage stability, dealing with immune responses, and navigating regulatory challenges for approval.
Article Synopsis
- Leishmaniasis is an infection caused by protozoa from the Leishmania genus, leading to various clinical forms including cutaneous and visceral types.
- Sporotrichoid cutaneous leishmaniasis (SCL) is a rare variation of cutaneous leishmaniasis primarily found in the Old World.
- A case report details a Japanese man in Peru infected with Leishmania (Viannia) peruviana; his lesions spread from one foot to the lymph nodes, and resolved with treatment using intravenous liposomal amphotericin B, marking the first recorded case of SCL from this specific pathogen.
Article Synopsis
- The study presents a new phagemid-based system that produces CRISPR-Cas13a-loaded antibacterial capsids (AB-capsids) specifically targeting multidrug-resistant Staphylococcus aureus.
- By optimizing phagemid copy numbers, researchers achieved higher yields and purity of AB-capsids, illustrating a direct relationship between phagemid quantity and capsid production.
- The developed AB-capsids effectively eliminate targeted S. aureus strains while leaving non-target strains unharmed, showcasing their potential as effective tools against antibiotic-resistant bacteria.