Publications by authors named "T Guru Prasad"
Background: Investigator-initiated trials (IITs) may address important biological and clinical questions that may not be prioritized by pharmaceutical sponsors. However, little is known about the process by which IIT proposals are evaluated and activated.
Methods: We performed a retrospective study of IIT concepts submitted through the Academic Thoracic Oncology Medical Investigators Consortium (ATOMIC), which comprises 13 institutions in the U.
The versatile nature of the urease enzyme makes it a valuable asset in biological and industrial contexts. The creation of bioconjugates using enzyme-polymer combinations has extended the shelf life and stability of urease. A triblock copolymer, PAM-co-PDPA-co-PMAA@urease (ADM@urease), was synthesized using acrylamide (AM), 2,5-dioxopyrrolidin-1-ylacrylate (DPA), methacrylic acid (MAA), and urease via the RAFT-Grafting-To polymerization method.
View Article and Find Full Text PDFBackground: Racial and ethnic disparities have been reported for HCC prognosis, although few studies fully account for clinically important factors and social determinants of health, including neighborhood socioeconomic status.
Methods: We conducted a retrospective multicenter cohort study of patients newly diagnosed with HCC from January 2010 through August 2018 at 4 large health systems in the United States. We used multivariable logistic regression and cause-specific Cox proportional hazard models to identify factors associated with early-stage HCC presentation and overall survival.
Article Synopsis
- The study addresses the difficulties in diagnosing pleural tuberculosis (TB) and introduces a new method called magnetic-bead-gold nanoparticle-PCR amplified immunoassay (MB-AuNP-I-PCR) to improve detection.
- The method was tested on 99 clinical specimens and demonstrated a sensitivity of 85.2% and a specificity of 97.8%, which was significantly better than other existing diagnostic techniques.
- The researchers emphasize that while the results are promising, further testing with a larger sample size is needed to validate the effectiveness of the MB-AuNP-I-PCR method for diagnosing pleural TB.